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KMID : 0360319950270020247
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 2 p.247 ~ p.252
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A Study of Oncogene Expression in Thyroid Tumor
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Abstract
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Current models for tumorigenesis propose that a series of genetic alterations occur during the progression from the normal cell to the malignant phenotype. Expression of three oncogenes(c-myc, c-erb B2 and c-Ha ras) have been identified in may
human
neoplasms, including thyroid nodule. In this study we evaluate expression of oncogenes in benign and malignant thyroid nodules with immunohistochemical staining methods using monoclonal antibodies to products of the oncogenes. The rates of
expression of
c-myc, c-erb B2 and c-Ha ras oncogenes were 3.6%, 35.7% and 25.0% in benign nodules and 44.4%, 94.4% and 50.0% in carcinomas. The positive rates of c-myc and c-erb B2 oncogenes were significantly higher in carcinomas than in benign nodules. There
was
positive relationship bwtween the rate of expression of c-myc oncogene and the size of carcinomas. There was no positive relationship bwtween the rates of expression of oncogenes and the status of lymph node metastasis. Results suggest that c-myc
anc
c-erb B2 oncogenes are related to the development and progression of thyroid carcinoma and c-myc oncogene can be used to evaluate prognosis of thyroid cancer patients.
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KEYWORD
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